Thread for Medical - Brain can re-wire itself Index | New Thread | Reply | Close | Stick | Delete  Medical - Brain can re-wire itself Edzz 4:39pm, July 04, 2006 [Edit] [Delete] Man's brain rewired itself, doctors contend Nerve connections severed in accident nearly 20 years ago By Karen Kaplan, Los Angeles Times | July 4, 2006 LOS ANGELES -- Terry Wallis awoke from a coma-like state 19 years after tumbling over a guardrail in a pickup truck and falling 25 feet into a dry riverbed. Now doctors armed with some of the latest brain-imaging technology think they may know part of the reason why. Wallis showed few outward signs of consciousness, but his brain was methodically rebuilding the white-matter infrastructure necessary for him to interact with the outside world, researchers reported yesterday in the Journal of Clinical Investigation. ``I believe it's a very, very slow self-healing process of the brain," said Henning Voss, lead author of the study and a physicist at Weill Cornell Medical College's Citigroup Biomedical Imaging Center. Wallis emerged from a minimally conscious state in 2003 at the age of 39 and uttered his first word since Ronald W. Reagan was in the White House: ``Mom." Since then, the onetime mechanic from Big Flat, Ark., has regained the ability to form sentences and recovered some use of his limbs, though he still can't walk or feed himself. Using both Positron Emission Tomography scans and an advanced imaging technique called diffusion tensor imaging, the researchers examined Wallis's brain after he regained full consciousness, and found that cells in the relatively undamaged areas had formed new axons, the long nerve fibers that transmit messages between neurons. ``In essence, Terry's brain may have been seeking out new pathways to reestablish functional connections to areas involved in speech and motor control -- to compensate for those lost due to damage," said the study's senior author, Dr. Nicholas Schiff, a neurologist at the Weill Cornell Medical College in New York. Schiff cautioned that Wallis was a ``1 in 300 million" case. But Dr. Steven Laureys, a neurologist at the University of Liege in Belgium, said the findings will force doctors to reconsider the way they treat patients who are in minimally conscious and persistent vegetative states. ``It does show there are changes happening" in the brain, said Laureys, who coauthored a commentary that also appears in the journal. ``It obliges us to reconsider old dogmas." In a minimally conscious state, a patient shows intermittent signs of awareness but generally is unable to interact with the outside world. It is a less severe condition than a persistent vegetative state, in which the patient is awake but has no awareness of herself or her surroundings. Terri Schiavo, the Florida woman at the center of a right-to-die battle, had been in a persistent vegetative state for 15 years when her husband won a court order to have her feeding tube removed last year. Neurologists believe that the longer a patient remains in a minimally conscious or persistent vegetative state, the lower the chances for recovery. As a result, such patients are often neglected by doctors and insurance companies, and it can be difficult for family members to find facilities that will accept them, Laureys said. In his last few years at Stone County Nursing and Rehabilitation Center in Mountain View, Ark., Wallis's family began to notice that Terry, a Ford enthusiast, would grunt when a Chevrolet commercial came on the television. They said he answered questions by blinking his eyes. About two years before he regained full consciousness, he began taking the antidepressant Paxil, which his doctors think may have contributed to his recovery. Within a week of his first utterance, Wallis began speaking in simple sentences. Once paralyzed from the neck down, he can now point with his left hand and move both legs. The researchers scanned Wallis's brain eight months after his awakening and found strong evidence that axons were making new connections in the cerebellum, the region that controls movement. The activity was stronger than in the brains of 20 healthy people scanned for the sake of comparison, and seemed to correlate with Wallis's physical improvement, Voss said. When his brain was rescanned 18 months later, signs of growth in the cerebellum had leveled off, and other areas of the brain were using more energy. Wallis's language skills improved during that time; he learned to count to 25 without interruption, and his speech became more intelligible. But when the researchers looked for evidence of increased activity in the language centers of his brain, they found none. ``Maybe we just missed it, or maybe the language areas are unusable because important connections are missing," said Voss, who theorizes that another part of the brain may have picked up the slack. Voss and his colleagues also scanned the brain of a car accident victim who is still minimally conscious, and they found significant axonal regrowth as well. That patient, however, has not shown corresponding clinical improvement, according to the study   Bulldawg 2:07am, July 09, 2006 [Edit] [Delete] 1 in 300 million case...it give one lots to think abt...   Edzz 5:11pm, July 09, 2006 [Edit] [Delete] I think that the more they learn, the more they realize that it's really less they know. :) Does that make any sense? Ed :)   Bulldawg 5:00pm, July 10, 2006 [Edit] [Delete] Ed, I guess the more we learn, the more avenues it opens that we never knew were there, which leads to tons more questions that educated, brilliant ppl try very hard, and work very hard to find the answers to. LOL....Does that make any sense?   Edzz 5:04pm, July 12, 2006 [Edit] [Delete] No. :D   Bulldawg 12:12am, July 18, 2006 [Edit] [Delete] It sure seems that I really do just luv run-on sentences that go on and on and on that really make no sense to anyone except those that are loosely "wired" like I am otherwise they'd get nothing out of reading such inane drivel such as this except for the cheap thrill of it and just anyway at all to waste their time and maybe it just beats going to the local ford dealer's showroom or watching paint dry as fun as that can be to paint purists on the loose..........ok, where was I going w/ this? Ed, do you understand? ;-)))   Edzz 4:03pm, July 18, 2006 [Edit] [Delete] No. :D Index | New Thread | Reply | Close | Stick | Delete